Abdelgaleil, S., Shiono, Y., Taktak, N. E. M., Saad, M. M. G. (2024). Herbicidal and Insecticidal Activity of Secondary Metabolites from Endophytic and Soil Fungi. , 26(4), 873-884. doi: 10.22034/JAST.26.4.873
S. Abdelgaleil; Y. Shiono; N. E. M. Taktak; M. M. G. Saad. "Herbicidal and Insecticidal Activity of Secondary Metabolites from Endophytic and Soil Fungi". , 26, 4, 2024, 873-884. doi: 10.22034/JAST.26.4.873
Abdelgaleil, S., Shiono, Y., Taktak, N. E. M., Saad, M. M. G. (2024). 'Herbicidal and Insecticidal Activity of Secondary Metabolites from Endophytic and Soil Fungi', , 26(4), pp. 873-884. doi: 10.22034/JAST.26.4.873
Abdelgaleil, S., Shiono, Y., Taktak, N. E. M., Saad, M. M. G. Herbicidal and Insecticidal Activity of Secondary Metabolites from Endophytic and Soil Fungi. , 2024; 26(4): 873-884. doi: 10.22034/JAST.26.4.873

Herbicidal and Insecticidal Activity of Secondary Metabolites from Endophytic and Soil Fungi

Journal of Agricultural Science and Technology
Article 12, Volume 26, Issue 4, 2024, Pages 873-884    PDF (4.6 M)
Document Type: Original Research
DOI: 10.22034/JAST.26.4.873
Authors
S. Abdelgaleil* 1; Y. Shiono2; N. E. M. Taktak3; M. M. G. Saad1
1Department of Pesticide Chemistry and Technology, Faculty of Agriculture, El-Shatby, Alexandria University, Alexandria 21545, Egypt.
2Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata, 997-8555, Japan.
3Department of Tropical Health, High Institute of Public Health, Alexandria University, Alexandria, Egypt.
Abstract
Fungi are a good source for lead molecules in drug discovery and development. However, many compounds derived from fungi were not evaluated for their bioactivity against economic, agricultural, and public health pests. Twelve fungal secondary metabolites (1-12) were evaluated for herbicidal activity against Silybum marianum and insecticidal activity against Culex pipiens larvae. Among the tested metabolites, brefeldin A (6) and 6-eopxy-4-hydroxy-3-methoxy-5-methyl-cyclohex-2-en-1-one (11) showed potent herbicidal activity against S. marianum with complete inhibition of seed germination at 500 mg L−1. Compound 6 revealed an exceptional herbicidal activity as it caused complete inhibition of root growth and strong reduction in shoot growth (I = 74.5%) and germination (10.0%) at 25 mg L−1. In addition, dehydroaustin (9), phomaxanthone A (4) and deacetylphomaxanthone A (5) displayed a potent toxicity against fourth larval instar of C. pipiens with LC50 values of 3.27, 57.03 and 63.50 mg L−1, respectively. Based on the results of this study, compounds 4-6, 9 and 11 should be developed as natural pesticides.
Keywords
Bioactivity; Culex pipiens; Fungal metabolites; Natural products; Silybum marianum
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